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Immunoglobulin Content and Antibody Activity in Urine in Experimental Urinary Tract Infection^1,2,

From the Department of Internal Medicine, Veterans Administration Hospital, 4500 South Lancaster Road, Dallas, Texas 75216, and the University of Texas Southwestern Medical School at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235

Abstract

Immunoglobulin content and antibody content in urine were analyzed in rabbits following experimental urinary tract infection. IgA was present in urine from normal animals and in animals with urinary tract infection. Since it was present in urine whether it was synthesized locally or not, IgA in urine probably represents IgA excreted from serum. IgG was not present in urine from normal rabbits, but was present in urine from some animals with pyelonephritis. This IgG migrated as a fast component immunoelectrophoretically, had antibody activity, and had the capability of crossing renal and intestinal epithelium. This unique IgG probably represents IgG synthesized by a restricted population of cells within the infected kidney. IgG was present in urine from all animals with bladder infection and represents newly synthesized IgG which can cross the inflamed bladder mucosa.

Footnotes

¹ This work was supported by Veterans Administration Hospital Research, and by United States Public Health Service Research Grant 5 R01 HD 00851 from the National Institute of Child Health and Human Development.

² Requests for reprints should be addressed to Dr. James W. Smith, General Medical Research, Infectious Disease Section, 4500 South Lancaster Road, Dallas, Texas 75216.

³ Dr. Smith was a recipient of Research Career Development Award 1-KO4-A1 05097, from the National Institute of Allergy and Infectious Diseases, United States Public Health Service, during this study.

⁴ Dr. Hand was a recipient of Special Fellowship 1-F3-A1-40,467 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service. His present address is Veterans Administration Hospital and Emory University School of Medicine, Atlanta, Georgia.