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Serial Passive Transfers of Immune Response by an Immune Ribonucleic Acid Preparation

From the Department of Microbiology, School of Medicine, Gunma University, Maebashi, Japan

Abstract

An immune ribonucleic acid (RNA) preparation was extracted with phenol from the spleens of mice immunized with Salmonella flagella. This material was able to induce immunologic memory cells to respond to a secondary antigen stimulus. Administration of actinomycin D inhibited this ability of immune RNA. The ability to induce the immunologic memory cells with immune RNA was serially and passively transfered to mice by an RNA fraction extracted from spleens of mice. Administration of actinomycin D, however, inhibited this ability of immune RNA to transfer serially immunologic memory. These results suggest that the immune RNA is functional per se and capable of replicating actively in recipient cells, although the mechanisms still remain unknown.