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Thymus-Derived Lymphocytes Sequestered in the Bone Marrow of Hydrocortisone-Treated Mice¹

Division of Clinical Immunology, Department of Medicine, University of Colorado Medical School, Denver, Colorado 80220

Abstract

Bone marrow cells from hydrocortisone-treated donor mice are immunocompetent by themselves after transfer with sheep erythrocyte antigens to irradiated syngeneic recipients. Such cell suspensions do not synergize with thymus. This indicates that such marrow, unlike normal marrow, contains both B and T lymphocytes. The immunocompetence of hydrocortisone-treated marrow is abolished by anti- serum and restored by thymus cells. These results are compatible with the sequestration of peripheral T lymphocytes in bone marrow after treatment with hydrocortisone.

Footnotes

¹ This research was supported in part by United States Public Health Service Grants AM10145 and TI AI-00013.

² Fellow of the Canadian Medical Research Council. Present address: National Institute for Medical Research, Mill Hill, London.