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Effect of C3 Inactivator on Bound C3 Antigen

Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The effect of C3 inactivator (C3ina) in human EDTA plasma on C3 antigen bound to various immune complexes was determined. C3ina greatly decreased the amount of C3 bound to human erythrocytes sensitized with IgM anti-I cold agglutinin, and also decreased erythrocyte-bound C3 of a patient with deficiency of C3 inactivator, but had little effect on C3 bound to human red cells sensitized with Donath-Landsteiner IgG cold agglutinin. C3ina did not alter the amount of human C3 antigen bound to sheep E, to pneumococcal polysaccharide-antibody precipitate and to Sepharose-2B beads. Although C3ina did not alter the amount of C3 antigen on sheep E, a change in the molecule must have occurred since immune adherence was abolished. These data along with evidence from the literature show that several stages of bound C3 inactivation can occur.