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The Antigens of Varicella-Zoster Virus¹

Department of Pediatrics, New York University School of Medicine, New York, New York 10016

Abstract

Precipitin antigen was prepared from cultures infected with V-Z virus. Five separate antigens were identified. Reactions with radiolabeled antigen were detected by autoradiography. Partial purification of antigens could be accomplished in a discontinuous sucrose gradient, yet too little antigen was recovered from DEAE to make this a practicable purification method. Most of the antigenic activity was eluted from G-200 Sephadex. Antigens were identified by their degree of chemical stability. The antigen was the only one which was stable at pH 3. The antigen was destroyed by CsCl or DOC. DOC released the , and antigens from the infectious viral particle.

Footnotes

¹ This work was supported by Grant No. AI-06880 of the National Institutes of Health, Grant No. CC00465 of the Center for Disease Control and a grant from the World Health Organization.