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Competition between L- and D-Synthetic Copolymers at the Level of the Macrophage¹

Institute of Microbiology, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey 08903

Abstract

Synthetic copolymers composed of l or d amino acids exhibit differential binding ability to the unique ribonucleoprotein (RNP) of peritoneal macrophage cells. The l-copolymers are bound eight to ten times as well as the d-copolymers. Despite the low level of binding of the d-copolymers, these compounds are capable of suppressing the binding of the l-copolymers to the RNP molecule. This effect appears to depend on the resistance of these polymers to catabolism as well as their high negative charge.

Footnotes

¹ This work was supported by National Institutes of Health Grant AI 9850-02 and National Science Foundation Grant GB-16871 and by a fellowship to R. H. Schwartz from the American Cancer Society.