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Surface Antigen Produced by Herpes Simplex Virus (HSV)

Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214

Abstract

Surface antigen of cells infected with herpes simplex virus (HSV) was studied by mixed agglutination technique. The surface antigen was stable to heat at 56°C, formalin, periodate and 2-4-dinitrophenol, but was not detected after treatment with acetone or ethanol. Surface antigen preceded infectious virus and required protein synthesis. DNA synthesis was not required since cytosine arabinoside did not inhibit production of surface antigen. HSV surface antigen was not shared by other members of the herpesvirus group. Detection of surface antigen by mixed agglutination was distinguished from surface conditions responsible for adherence of sensitized sheep erythrocytes.

Footnotes

¹ Recipient of a Henry C. and Bertha H. Buswell Fellowship.