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The Purification of Adenovirus Neutralizing Antibody: Adenovirus Type 5 Hexon Immunoadsorbent

National Institute for Medical Research, Mill Hill, London NW7 1AA, England

Abstract

Preparation of an immunoadsorbent of crystalline hexon of adenovirus type 5 bound to Sepharose is described. The immunoadsorbent was employed to purify antibody to adenovirus type 5 hexon from antiserum prepared against a mixture of the three capsid antigens. In addition, separation of antibody with type-specific neutralizing activity from group-specific non-neutralizing hexon antibody has been achieved.

Footnotes

¹ Now with Veterans Administration Hospital, San Francisco, California.

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