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Two New Antigens of Human IgG, "Non b⁰" and "Non b¹," Related to the Gm System

Institute of Immunology and Rheumatology, Rikshospitalet, Oslo 1, Norway

Abstract

A hidden rheumatoid factor, reacting with a human IgG antigen, called "non b", present on all Gm(b) negative IgG3 proteins, and also on all IgG1 and IgG2 proteins, but not on IgG3 Gm(b) or IgG4, was revealed by gel filtration. A similar specificity was demonstrated in two properly absorbed baboon antisera against human myeloma proteins. The "non b" antigen could be further divided into "non b¹," detected by the rheumatoid anti-"non b" and by one of the baboon antisera, and "non b⁰" detected by the other hetero-antiserum. The "non b⁰" antigen was present on the pFc' and Fc' fragments of human IgG, whereas "non b¹" was found to be present on Fc outside pFc. This subdivision of "non b" was further supported by experiments with selected IgG3 myeloma proteins and anti-Rh antibodies.'

The "non b⁰" and "non b¹" antigens reflect the close relationship among the IgG subclass proteins and may be valuable markers in studying the evolution of the IgG subclasses.

Footnotes

¹ Fellow of the Norwegian Council for Science and the Humanities.