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The Distribution of Alloantigenic Specificities of Native H-2 Products¹

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461

Abstract

Studies on radiolabeled, detergent-solubilized H-2 alloantigens of two different genotypes with indirect immunoprecipitation show that at least two different antigen molecules can be isolated from cells of each genotype. These H-2 alloantigen molecules may bear the antigenic sites for one, two or more specificities. The findings are consistent with recent views that the H-2 genetic region includes two genes, each of which directs the synthesis of a different H-2 alloantigen molecule.

Footnotes

¹ This investigation was supported in part by United States Public Health Service Grants 5TI-AI-00307, 5T5-GM-1674, by National Institutes of Health Grant AI-07289, National Science Foundation Grant 7924, and by United States Public Health Service Contract PH-43-68-1295.

² Stanley G. Nathenson is the recipient of a Research Career Development Award from the United States Public Health Service, (AI-11569).