HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gershon, R. K. Articles by Liebhaber, S. A. Search for Related Content PubMed Articles by Gershon, R. K. Articles by Liebhaber, S. A.

Suppressor T Cells

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510

Abstract

The antigen-induced DNA synthetic response of a number of different thymocyte populations was studied in the spleens of lethally irradiated recipients by incorporation of ¹²⁵I 5-iodo-2-deoxyuridine. The response of certain cell combinations was not only less than the sum of the two responding alone but less than one of the individual cell populations in the combination. The following combinations had this effect: 1) "Educated" and normal thymocytes < "educated" alone in the response to sheep red cells (SRBC); 2) parental and F₁ thymocytes < parental alone in F₁ hosts; 3) cortisone resistant (in a low dose) and normal thymocytes < normal alone in the response to SRBC. Thus, thymocytes are capable of suppressing the antigen-induced response of other thymocytes without the mediation of B cells or their product (i.e., antibody).

This article has been cited by other articles:

				N. B. Marshall, W. R. Vorachek, L. B. Steppan, D. V. Mourich, and N. I. Kerkvliet Functional Characterization and Gene Expression Analysis of CD4+CD25+ Regulatory T Cells Generated in Mice Treated with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin J. Immunol., August 15, 2008; 181(4): 2382 - 2391. [Abstract] [Full Text] [PDF]

				S. Calbo, H. Delagreverie, C. Arnoult, F.-J. Authier, F. Tron, and O. Boyer Functional Tolerance of CD8+ T Cells Induced by Muscle-Specific Antigen Expression J. Immunol., July 1, 2008; 181(1): 408 - 417. [Abstract] [Full Text] [PDF]

				P. B. Watchmaker, J. A. Urban, E. Berk, Y. Nakamura, R. B. Mailliard, S. C. Watkins, S. M. van Ham, and P. Kalinski Memory CD8+ T Cells Protect Dendritic Cells from CTL Killing J. Immunol., March 15, 2008; 180(6): 3857 - 3865. [Abstract] [Full Text] [PDF]

				Y. Nakamura, P. Watchmaker, J. Urban, B. Sheridan, A. Giermasz, F. Nishimura, K. Sasaki, R. Cumberland, R. Muthuswamy, R. B. Mailliard, et al. Helper Function of Memory CD8+ T Cells: Heterologous CD8+ T Cells Support the Induction of Therapeutic Cancer Immunity Cancer Res., October 15, 2007; 67(20): 10012 - 10018. [Abstract] [Full Text] [PDF]

				M. Salagianni, W. K. Loon, M. J. Thomas, A. Noble, and D. M. Kemeny An Essential Role for IL-18 in CD8 T Cell-Mediated Suppression of IgE Responses J. Immunol., April 15, 2007; 178(8): 4771 - 4778. [Abstract] [Full Text] [PDF]

				F. L. Ierino, K. Yamada, T. Hatch, J. Rembert, and D. H. Sachs Peripheral Tolerance to Class I Mismatched Renal Allografts in Miniature Swine: Donor Antigen-Activated Peripheral Blood Lymphocytes from Tolerant Swine Inhibit Antidonor CTL Reactivity J. Immunol., January 1, 1999; 162(1): 550 - 559. [Abstract] [Full Text] [PDF]

				D. A. Silverman and N. R. Rose Neonatal Thymectomy Increases the Incidence of Spontaneous and Methylcholanthrene-Enhanced Thyroiditis in Rats Science, April 12, 1974; 184(4133): 162 - 163. [Abstract] [PDF]

				D. A. Rowley, F. W. Fitch, F. P. Stuart, H. Kohler, and H. Cosenza Specific Suppression of Immune Responses Science, September 21, 1973; 181(4105): 1133 - 1141. [Abstract] [PDF]