HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Krüger, J. Articles by Gershon, R. K. Search for Related Content PubMed Articles by Krüger, J. Articles by Gershon, R. K.

DNA Synthetic Response of Thymocytes to a Variety of Antigens

Department of Microbiology and Pathology, Yale University School of Medicine, New Haven, Connecticut 06510

Abstract

The ability of 10 different antigens to stimulate uptake of ¹²⁵I UDR, as a measure of DNA synthesis in T cells,¹ was investigated. There was a good correlation between the stimulatory capacity of the antigens and their antigenicity. Five of the antigens studied have been reported to be "thymus-independent.". Three of them (brucella, POL and ferritin) were among the best T cell stimulators while the other two (pneumococcal polysaccharide and PVP) were the poorest. This discrepancy suggests that the basis of their reported "thymus-independency" is different. An explanation for the difference is offered.

Footnotes

¹ Abbreviations used in this paper: BGG, bovine globulin; BSA, bovine serum albumin; DNP, 2,4-dinitrophenyl; KLH, keyhole limpet hemocyanin; PnII, purified capsular polysaccharide of type II Pneumococcus; PnIII, purified capsular polysaccharide of type III Pneumococcus; POL, polymerized flagellin of Salmonella adelaide; PVP, polyvinylpyrrolidone; SRBC, sheep red blood cells; IUDR, 5-iodo-2-deoxyuridine; FUDR, 5-fluoro-2-deoxyuridine; B cells, Non-thymus derived-antibody-making precursor cells; T cells, thymus-processed lymphocytes; µCi, Microcuries.