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Studies on Immunoglobulins of Mink: Definition of IgG, IgA and IgM

United States Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratory, Hamilton, Montana 59840

Abstract

Three major Ig classes, IgG, IgA and IgM were characterized in mink serum. Mink IgM was a globulin and was changed from 19S to about 6 to 7S after mild reduction and alkylation. IgA was found in serum, urine and saliva, although the greatest concentration of IgA was found in intestinal contents. The IgA's in various fluids appeared antigenically identical, migrated as proteins and sedimented as 12 to 13S molecules. Only serum IgA, however, was mainly 7S after mild reduction and alkylation.