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The Immunogenicity of Adenovirus Type 5 Structural Proteins¹

National Institute for Medical Research, Mill Hill, London NW7 1AA, England

Abstract

The immunogenicity of two adenovirus structural proteins, hexon and fiber of adenovirus type 5, has been investigated. The lowest dose of antigen capable of inducing a primary immune response in guinea pigs was found to be 1 ng and 100 ng, respectively, for the two antigens. The immunogenicity of adenovirus antigens is discussed with respect to antigens from other microorganisms and vaccination with virus subunits.

Footnotes

¹ This work was partly supported by a grant from The Anna Fuller Foundation.

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