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Immunologic Deficiencies in Senescence

II. Characterization of Extrinsic Deficiencies¹

University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences and the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Abstract

The purpose of this investigation was to characterize immunologic deficiencies which occur in senescent mice. Extrinsic deficiencies, i.e., environmental deficiencies, were studied by transfer of immunocompetent cells into either young or old mice and assessment of the capacity of the cells to generate IgM antibody-forming cells. Non-cellular (environmental) factor(s) in the old mice were observed to be detrimental to the rate of growth of the antibody-forming cell population and to the full expression of the immune potential of normal young immunocompetent cells.

Footnotes

¹ Research sponsored by the United States Atomic Energy Commission under contract with the Union Carbide Corporation. A portion of the work was presented at the annual meeting of the Federation of American Societies for Experimental Biology, April 1971, Chicago, Illinois.

² United States Public Health Service Predoctoral Fellow (5-F01-GM-40, 756-03). Present address: Division of Biological Sciences, Ontario Cancer Institute, Toronto, Ontario, Canada.