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Immunologic Deficiencies in Senescence

I. Characterization of Intrinsic Deficiencies¹

University of Tennessee—Oak Ridge Graduate School of Biomedical Sciences and the Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830

Abstract

The purpose of this investigation was to characterize immunologic deficiences which occur in senescent mice. Deficiencies intrinsic to the principal cell populations that participate in the events leading to production of specific antibody-forming cells in response to antigen stimulation were analyzed by limiting-dilution and dose-response analyses. A quantitative increase in thymus-derived cell frequency and a decrease in bone marrow-derived cell frequency were found. Both old thymus-derived and old bone marrow-derived cells were found to be less capable of growth and proliferation than the respective young cell populations. Efficiency of antigen processing was found to be reduced by about 10-fold, as judged by the minimum amount of antigen necessary for maximum stimulation of the immune system in young and in old mice.

Footnotes

¹ Research sponsored by the United States Atomic Energy Commission under contract with the Union Carbide Corporation. This research was submitted in partial fulfillment of requirements for a doctoral degree. A portion of the work was presented at the annual meeting of the Federation of American Societies for Experimental Biology, April 1971, Chicago, Illinois.

² United States Public Health Service Predoctoral Fellow (5-F01-GM-40, 756-03). Present address: Division of Biological Sciences, Ontario Cancer Institute, Toronto, Ontario, Canada.

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