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Cytochalasin B

IV. Inhibition and Stimulation of Chemotaxis of Rabbit and Human Polymorphonuclear Leukocytes¹

Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut 06032 and the Department of Pediatrics and Pathology, University of Minnesota College of Medicine, Minneapolis, Minnesota 55455

Abstract

Cytochalasin B (2 to 4 µg/ml) reversibly inhibits the chemotactic response of human and rabbit polymorphonuclear leukocytes to a bacterial chemotactic factor or to the complement derived factor, C5a. At lower concentrations (1 to 0.1 µg/ml or less) Cytochalasin B actually stimulates chemotaxis. Spontaneous movement of the leukocyte is reversibly inhibited at concentrations as low as 0.2 µg/ml. Enhancement of the spontaneous motility has not been observed at this or lower concentrations.

Footnotes

¹ This study was supported by United States Public Health Service Grant AI-09648 to E. L. B., and in part by United States Public Health Service Grants AI-08821 and AI-06931 and in part by a grant from the Minnesota Arthritis Foundation, the United States Army Medical Research and Development Command under Contract No. DADA 17-69-C-9182 and the Elsa U. Pardee Foundation.

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