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Transfer of Experimental Allergic Orchitis with Peritoneal Exudate Cells¹

Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Experimental allergic orchitis (EAO) was transferred to strain 13 guinea pigs by the intratesticular injection of sensitized peritoneal exudate cells (PEC) obtained from syngeneic donors immunized with a testicular antigen in complete Freund's adjuvant (CFA). The lesions were antigen and organ specific, developed within 24 hr of transfer, consisted of macrophages and polymorphonuclear leukocytes (PMN) within the seminiferous tubules, rete testes and interstitial tissues and resulted subsequently in aspermatogenesis. When contrasted to similar lymph node transfer studies, sensitized PEC transfers induced lesions earlier and more frequently, required fewer total cells and lymphocytes per transfer, resulted in a more intense infiltrative process, particularly in the rete testis and produced lesions in irradiated recipients. It appeared that as few as 2 x 10⁵ transferred lymphocytes were needed to induce an immunologic lesion in the presence of phagocytic effector cells.

Footnotes

¹ This is publication 546 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation. This research was supported by United States Public Health Service Grant AI-07007 and Atomic Energy Commission Contract AT(04-3)-410. G.L.K. is a recipient of Special Fellowship 5 F03 AM47849-02 from the National Institute of Arthritis and Metabolic Diseases.

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