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Receptors for Immunoglobulin and Complement on Mouse Leukemias and Lymphomas

Laboratory of Immunology and the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, and the Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014

Abstract

Bone marrow-derived B lymphocytes bear a receptor for antigen-antibody-complement complexes (EAC). Monocytes and macrophages also bear a receptor for EAC, but require the Mg⁺⁺ ion for the attachment of EAC. A receptor for red cell IgG complexes (EA) is found on monocytes, but not on lymphocytes. Twenty-one mouse leukemias and lymphomas were examined for the presence of these receptors. None of the tumors studied bore the lymphocyte EAC receptor. One tumor bore both the monocyte EAC and EA receptors; two of the tumors bore the monocyte EA receptor alone. The binding of the IgG EA complex to both these tumor cells and to normal monocytes could be inhibited only by mouse myeloma proteins of the F (₁) and H (_2b) subclasses of mouse IgG.