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Precipitin Reactions between Polyribonucleotides and Heat Labile Serum Factors¹

Division of Allergy and Immunology and the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Immunodiffusion in agarose was used to study precipitin reactions between synthetic polyribonucleotides and human sera. A high incidence of precipitin lines was observed between certain polyribonucleotides and normal human sera. These were due to heat labile serum factors, one of which was related to C1q component of complement. In addition, heat stable serum factors were present in a few systemic lupus erythematosus sera which precipitated with polyribonucleotides. The latter precipitin reactions could be abolished by absorption of sera with heat-denatured single-stranded DNA.

Footnotes

¹ Supported by United States Public Health Service Grants AM 12198 and AI 00214 from the National Institutes of Health. This is Publication No. 537 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California.

² Senior Investigator, The Arthritis Foundation.