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Alteration in Graft vs Host Reactivity and in Hematopoietic Stem Cells of Spleen Cell Inocula from Donor Mice Pretreated with Pertussis Antigen

From the Department of Experimental Pathology, Armed Forces Radiobiology Research Institute, Bethesda, Maryland 20014

Abstract

The graft versus host reactivity (GVHR) and hematopoietic stem cells of spleen cell inocula were assayed 3 days after pretreatment of donor mice with heated or unheated pertussis vaccine. Unheated vaccine reduced GVHR to 17% of control reactivity, measured by the Simonsen spleen weight assay, and increased 2.2-fold the proportion of hematopoietic stem cells, assayed as colony forming units (CFU). Heated vaccine, which did not produce the lymphocytosis induced in donors by unheated vaccine, reduced GVHR to 38% of control reactivity, and increased the proportion of CFU 3.8-fold. Alternative mechanisms for these effects are discussed.

Footnotes

¹ Present address: The Johns Hopkins Hospital, Department of Nuclear Medicine, 615 N. Wolfe Street, Baltimore, Maryland.

² Present address: National Institute of Neurologic Disease and Stroke, National Institutes of Health, Bethesda, Maryland 20014.