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In Vitro Immunity to TNP and Penicillin: Specific Inhibition with Hapten-Conjugated Isologous Red Cells¹

From the Department of Bacteriology and Immunology, University of California, Berkeley, California

Abstract

Syngeneic mouse red cells conjugated with trinitrophenyl (TNP) or penicillin inhibit immune responses to these haptens in vitro, The inhibition is specific and requires a significant excess of inhibiting red cells over immunogenic red cells. Inhibition is probably due to competition for specific binding sites during the initiation of the response, since the inhibitor must be present at the time of immunization. Specific inhibition with free haptens was not observed.

Footnotes

¹ This work was supported in part by Research Grants AI-06610 and AI-08817 from the National Institutes of Health, and by funds from the Driesman Amie Fund and Cancer Research Coordinating Committee Fund.

² Recipient of Fellowship 5F05-TW-1509-02 from the United States Public Health Service. Present address: Department of Immunology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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