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Genetic Control of Immune Response to -AKR Alloantigen¹

From the Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214

Abstract

Primary immune responses of -C3H mouse strains, inbred Swiss Webster (RR) and C57BL/6 to thymic alloantigen -AKR, as measured by plaque assay detecting IgM-antibody-producing cells, were shown to be under genetic control. F₁ hybrids of the high responder, RR, and the low responder, C57BL/6, were intermediate responders. The experiments with backcrosses, F₁ x RR and F₁ x C57BL/6, suggested that a pair of allelic genes both of which are expressed and which are closely associated with H-2 locus are responsible for the control.

The low responder state of C57BL/6 mice could be overcome to a great extent by higher dose of the antigen. Both RR and C57BL/6 mice developed responses of similar magnitude to heterologous erythrocytes.

The results of these experiments indicated that the genetic control of anti- response may be exerted at the level of the initiation of the specific immune response.

Footnotes

¹ Supported by United States Public Health Service Research Grant AI-06754 from the National Institute of Allergy and Infectious Diseases.

² Recipients of Henry C. and Bertha H. Buswell Fellowships.