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Correlations between the Concentrations of the Four Sub-Classes of IgG and Gm Allotypes in Normal Human Sera¹

From the Department of Immunology, Swiss Center for Clinical Cancer Research, Tiefenau, Bern, Switzerland, The Department of Biology, Case Western Reserve University, Cleveland Ohio, The Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands, and the Immunology Branch of the National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Abstract

The concentrations of the four subclasses of IgG were determined in the sera of 108 young male adults. The relative concentrations are 60.9% for IgG1, 29.6% for IgG2, 5.3% for IgG3 and 4.2% for IgG4. Mean concentrations of IgG2 and IgG4 are higher in sera positive for Gm(23) than in sera lacking this genetic marker. High mean IgG3 concentrations are associated with sera homozygous and heterozygous for Gm(3,5,13,14).

Footnotes

¹ This work was supported by the Swiss National Foundation for Scientific Research.

² Swiss Center for Clinical Cancer Research, Tiefenau, 3004 Bern, Switzerland.

³ Case Western Reserve University, Cleveland, Ohio 44106.

⁴ Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands.

⁵ National Cancer Institute, Immunology Branch, National Institutes of Health, Bethesda, Maryland 20014.

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