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The Journal of Immunology, 1972, 108: 183-194.
Copyright © 1972 by The American Association of Immunologists, Inc.
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Use of Chicken Tracheal Organ Cultures for Studying Resistance of Respiratory Epithelium to Viral Infection

Martin S. Finkelstein1, Michael McWilliams2 and Charles G. Huizenga

From the United States Air Force School of Aerospace Medicine, Brooks Air Force Base, Texas 78235, the Department of Medicine, New York University School of Medicine, and Irvington House Institute, New York, N.Y. 10016

Abstract

Chicken tracheal explants have been used for measuring tracheal resistance to virus infection. This model offers many advantages over studies in intact animals. Resistance can be stimulated in vitro or in the donor animal in vivo. Preliminary results show that tracheal resistance, mediated at least in part by interferon, was dependent upon the route used to administer the interferon inducer. Interferon was not detected in the trachea or serum of protected chickens at the time studied. Antiviral resistance could also be stimulated in the donor chicken by prior immunization. Tracheal resistance developed only in those chickens immunized by the intra-tracheal route. Resistance correlated with tracheal, but not with serum antibody titer. Resistance could be partially blocked by exogenously applied rabbit anti-chicken globulin, suggesting that some of the antibody responsible for the protection was located in superficial sites.

Footnotes

1 Present address: Department of Medicine, New York University School of Medicine, New York, N.Y.

2 Present address: Department of Epidemiology, University of California School of Veterinary Medicine, Davis, Calif. 95616.






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