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Further Characterization of the Local Respiratory Tract Antibody Response Induced by Intranasal Instillation of Inactivated Rhinovirus 13 Vaccine

From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The nasal secretory antibody response of volunteers vaccinated intranasally with an inactivated rhinovirus type 13 vaccine was further characterized. It appeared that intranasal vaccination induced resistance to challenge which lasted at least 6 months. The local neutralizing antibody which developed was specific for type 13 virus and this antibody persisted for at least 330 days following vaccination. Finally, there was a suggestion that the local respiratory tract secretory immune response possesses some degree of immunologic memory.

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