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Carboxy-Terminal Amino Acid Sequences of Canine Immunoglobulin G Subclasses

From the National Institutes of Health, Bethesda, Maryland 20014

Abstract

The carboxy-terminal octadecapeptides from canine heavy chains of 1) IgGa, b (from normal serum) and 2) IgGd (from a paraprotein) were isolated. The amino acid sequences of both octadecapeptides were determined. Both peptides are clearly homologous to the same heavy chain region of IgG's from other mammals. Previously it has been shown that canine IgGd and equine IgG (T) share certain biologic properties; however, comparison of the sequences of their C-terminal octadecapeptides reveals no uniquely shared residues which would support a close phylogenetic relationship.

Footnotes

¹ Present address: The Johns Hopkins University School of Medicine, Clinical Immunology Division, 5601 Loch Raven Boulevard, Baltimore, Md. 21239.

² Present address: Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas 75235.

³ Present address: Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, California 92037.