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Genetic Control of Immune Response to Glutamic Acid, Alanine, Tyrosine Copolymers in Mice^1,2,

I. Association of Responsiveness to H-2 Genotype and Specificity of the Response

From the Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania

Abstract

The immune responsiveness of 21 inbred and congenic strains of mice to two copolymers of L-glutamic acid, L-alanine and L-tyrosine, GAT¹⁰ and GAT⁴, was investigated. Mice of the H-2^a, H-2^b, H-2^d and H-2^k histocompatibility alleles were responders to GAT¹⁰, whereas strains possessing the H-2^f, H-2^j, H-2^p, H-2^q, H-2^r, H-2^s and H-2^w histocompatibility alleles were nonresponders, indicating an association between immune responsiveness and the H-2 locus. Although the response to GAT⁴ was also linked to H-2 locus as above, the P strain having the H-2^p allele produced a minimal response. The study of the specificity of the antibody produced with the cross-reacting polymers GA(T²) and GT indicated that the recognition of the antigenic determinant is under separate genetic control.

Footnotes

¹ This study was supported by Research Grant AI07825 from the National Institutes of Allergy and Infectious Diseases and American Cancer Society Grant T-452.

² Paper No. 45 in series on Antigenicity of Polypeptides (Poly Amino Acids).