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Synthesis, Assembly, and Secretion of Globulin by Mouse Myeloma Cells

IV. Assembly of IgA¹

Departments of Cell Biology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, and the National Cancer Institute, Bethesda, Maryland 20014

Abstract

The synthesis and assembly of mouse IgA has been examined in the Adj-PC 6A cell line and in the MOPC 209B and MOPC 315 tumors. The pathway of assembly of the IgA monomer in these tumors appears to be H + H H₂; H₂ + L + L H₂L₂; H₂L₂ + H₂L₂ (H₂L₂)_n. Final assembly of the monomers of 6A and 315 into IgA polymers occurs close to the time of secretion.

Footnotes

¹ This work was supported by grants from the National Science Foundation, American Cancer Society and the National Institutes of Health (AI 4153, AI 4231).

² Supported by a Senior Fellowship from the World Health Organization.

³ Recipient of a United States Public Health Service Career Development Award.