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Cyclophosphamide-Induced Tolerance to Equine Globulin and to Equine-Anti-Mouse-Thymocyte Globulin in Adult Mice

I. Studies on Antigen and Drug Requirements¹

From the Division of Experimental Biology, Baylor College of Medicine, Houston, Texas 77025

Abstract

Adult mice were made tolerant to equine globulin (EqGG) and to equine-anti-mouse-thymocyte globulin (ATG) by injection of EqGG (deaggregated, heat-aggregated, or in Freund's adjuvant) or ATG followed by cyclophosphamide (CY). Injection of deaggregated EqGG alone resulted in only "marginal" tolerance, whereas the other injections alone were immunogenic. The resulting tolerance could be shown to be of long duration without further antigen or drug injections. Relationships between the dose of CY required for tolerance induction and the timing of the drug in relation to antigen administration were established.

Footnotes

¹ This investigation was supported by United States Public Health Service Grants TO1-CA-05021, CA-03367 and K6-CA-14, 219.