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Titration and Typing of Serum Antibodies in Tric Infections by Immunofluorescence¹

From the Department of Microbiology and Proctor Foundation, University of California, San Francisco, California 94122, and Laboratoire de Recherches Virologiques, Institut d'Ophtalmologie, Tunis, Tunisia

Abstract

An indirect immunofluorescence test was employed to detect and quantitate serum antibodies to trachoma-inclusion conjunctivitis (TRIC) antigens of 6 types. This test was markedly more specific and sensitive than the group-reactive complement-fixation test. Striking differences in antibody patterns were detected in different groups of patients suffering from acute or chronic TRIC infections. Among Tunisian children 67% had antibody which was primarily directed against TRIC types A or C. Among American Indian students, 33% had antibody which was directed mainly against TRIC types B, D, or E, but not against A or C. Most San Francisco patients with acute oculogenital TRIC infection had antibodies broadly reactive with all 6 TRIC antigen types A to E. Some immunologic and epidemiologic implications of these results are discussed.

Footnotes

¹ This work was supported in part by the National Institutes of Health Grant EY 00186, the Burroughs-Wellcome Fund, and PL 480 07-075-2.