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Immune Response in Vitro to Salmonella H-Antigens, Not Affected by Anti-Theta Serum

MRC-Transplantation Unit¹ and the Department of Pathology, University of Alberta, Edmonton, Alberta, Canada Department of Pathology, University of Alberta, Edmonton, Alberta, Canada

Abstract

Treatment of mouse spleen cells with antiserum cytotoxic to theta antigens does not affect the subsequent immune response in vitro to Salmonella H-antigens. Similarly treated cells fail to initiate an immune response to sheep erythrocytes. This finding represents a strong argument for the existence of immune responses to certain antigens which do not require thymus-derived cells.

Footnotes

¹ Supported by the Canadian Medical Research Council.