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Evolution of Delayed Hypersensitivity Reactions in Man

Divisions of Immunology and Infectious Diseases, Rochester General Hospital and the University of Rochester School of Medicine, Rochester, New York

Abstract

Hill demonstrated that in guinea pigs intradermal injection of mild irritants resulted at 18 to 24 hr in a local infiltrate of predominantly mononuclear cells which resembled that seen in delayed type hypersensitivity (DTH) reactions induced by specific antigens (1). Measurable induration, however, was not present. When sites prepared in this manner were then injected with specific antigen, the appearance of edema and induration were markedly accelerated, reaching a peak in a few hours rather than the 24 hr required at control, nonprepared sites. Since the histological character of the reaction did not change appreciably after antigen injection, the only apparent result of specific challenge was the rapid appearance of induration. Those observations prompted a similar investigation into properties of naturally occurring DTH in humans.

Methods. Eleven experiments were performed in 9 volunteers. Two of the volunteers were used twice with an interval of 4 months between tests.