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Antibody Against Neoplastic Plasma Cells

II. Suppressive Effect on Antibody-Producing Cells¹

Department of Biochemistry Research, Rosearch, Roswell Park Memorial Institute,³ 666 Elm Street, Buffalo, New York 14203

Abstract

Rabbit antisera against cellular components of BALB/c mouse myeloma were found to contain antibodies which are specific for surface antigens present on both normal and neoplastic plasma cells. When spleen cells from mice previously immunized with sheep erythrocytes were exposed to the antisera and rabbit complement prior to assay, the formation of hemolytic plaques was strongly suppressed, even though the viability of spleen cells in general was not affected. The suppressive effects of anti-myeloma sera on direct and indirect plaque-forming cells (PFC) were similar in both primary and secondary responses. The suppressive effect was seen with PFC of all the inbred strains of mice tested. The surface antigens which react with the PFC-suppressive antibodies are also present on myeloma cells, but do not appear to be present in any significant amounts on lymphocytes of thymus, lymph node and spleen, or on cells of liver and kidney.

Footnotes

¹ This work was supported in part by Contract AT-(30-1)-2651 from the Atomic Energy Commission.

² On leave of absence from the Third Department of Internal Medicine, Osaka University School of Medicine, Osaka, Japan.

³ A unit of the New York State Department of Health.