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The Journal of Immunology, 1971, 107: 1699-1705.
Copyright © 1971 by The American Association of Immunologists, Inc.
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Bence Jones Proteins and Light Chains of Immunoglobulins

VI. Immunochemical Detection of Interclass Similarities Among {kappa}-Chains1,2,

Carla L. McLaughlin and Alan Solomon3

University of Tennessee Memorial Research Center and Hospital, Knoxville, Tennessee 37920

Abstract

Extensive immunochemical comparisons among {kappa}I, {kappa}II and {kappa}III Bence Jones proteins belonging to different {kappa}-chain groups can have identical antigenic sites in the amino terminal (variant) half of the light polypeptide chain. Certain antisera prepared against {kappa}-chains belonging to one group have the capacity to detect antigenic differences among proteins of another group, i.e., an anti-{kappa}I antiserum can differentiate among {kappa}III proteins. Immunochemical studies on Bence Jones proteins and light chains of known sequence and the subsequent integration of immunochemical and sequence data have permitted the localization of certain regions in the light polypeptide chain for which our antisera have specificity and which are responsible for the intragroup differences and intergroup similarities among {kappa}-chains.

Footnotes

1 This investigation was supported by United States Public Health Service Research Grant CA-10056-06 from the National Cancer Institute, American Cancer Society Grant T-420, and National Science Foundation Grant GB-6036.

2 Presented in part to the 55th annual meeting of the American Association of Immunologists, Chicago, Illinois, April, 1971.

3 Recipient of a Research Career Development Award (5-K03-CA-21,229) from the National Cancer Institute.






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