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Isolation of the Anticomplementary Protein from Cobra Venom and its Mode of Action on C3^1,2,

Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Abstract

Cobra factor, a protein of the venom of Naja naja, was isolated. It was characterized as a glycoprotein with a molecular weight of 144,000 and an electrophoretic mobility of a globulin at pH 8.6. Added to whole human serum it converted and inactivated C3. The effect on C3 was found to be dependent upon a non-complement plasma protein and on bivalent cations. To generate C3-directed enzymatic activity, cobra factor had to enter into a firm complex with the plasma protein, a 5S thermolabile pseudoglobulin.

Footnotes

¹ This is publication number 509 from the Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California 92037.

² This work was supported by United States Public Health Service Grant AI-07007 and United States Atomic Energy Commission Contract AT(04-3)-730.

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