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Antigen Binding Cells

II. Effect of Highly Radioactive Antigen on the Immunologic Function of Bone Marrow Cells¹

Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Bone marrow cells of non-immune mice are rendered immunologically incompetent by incubation with highly radioactive hemocyanin. Lethally irradiated mice that are reconstituted with such bone marrow cells respond poorly to KLH but well to sheep erythrocytes and exhibit a lower number of lymphocytes binding KLH in spleen. These results suggest that some bone marrow cells are already differentiated to respond immunologically to a given antigen.

Footnotes

¹ This research was supported by National Institute of Health Grant AI 10901.