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The Journal of Immunology, 1971, 107: 1512-1519.
Copyright © 1971 by The American Association of Immunologists, Inc.
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The Preparation of Human Kininogen

II. Further Characterization of Purified Human Kininogen1

Jocelyn Spragg2 and K. Frank Austen

Department of Medicine, Harvard Medical School at the Robert B. Brigham Hospital, Boston, Massachusetts 02120

Abstract

Highly purified human plasma kininogen was detected functionally and antigenically in order to establish its electrophoretic mobility, isoelectric point and molecular weight. The effect of specific and nonspecific treatment upon these parameters was assessed and it is suggested that the several human kininogens may in fact represent alterations of a single plasma protein.

Footnotes

1 This work was supported by Grants AI-07722 and FR-05669 from the National Institutes of Health.

2 Postdoctoral Fellow of the National Arthritis Foundation.






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