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Effect of Antigen Variation on Production of Antibody in Canine Tracheal Secretions¹

From the Department of Medicine Northwestern University McGaw Medical Center and Chicago Wesley Memorial Hospital, Chicago, Illinois, and the Smith Kline and French Laboratories, Philadelphia, Pennsylvania

Abstract

Mongrel dogs with tracheal pouches were immunized by pouch injection with bovine serum albumin (BSA), keyhole limpit hemocyamin (KLH) and sheep red blood cells (SRBC). Antibody responses were assayed in tracheal secretions and in serum. Antibody apparently gained access to tracheal secretions by two means. Antibodies to KLH and BSA in tracheal secretions appeared to have been produced systemically and transported to the pouch and into the secretions. In contrast, antibodies to SRBC were apparently manufactured locally as well as systemically, as shown by the presence of an IgA anti-SRBC that was detected in tracheal secretions but not in sera.

Footnotes

¹ This work was supported in part by United States Public Health Service Training Grant 5T01 A1-00057-10, by Research Grant 2 R01-A1 06139-06 from the National Institute of Allergy and Infectious Disease, and by the Ernest S. Bazley Asthma Research Fund to Chicago Wesley Memorial Hospital, Chicago, Illinois.

² Department of Medicine, Northwestern University.

³ Smith Kline and French Laboratories.