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Spontaneous Thyroiditis in the Obese Strain of Chickens

VI. Thyroxine-Binding Antibodies¹

From the Center for Immunology, and the Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214

Abstract

By means of radioimmunoelectrophoresis and radioelectrophoresis, thyroxinebinding antibodies were demonstrated on one or several occasions in about 16% of obese strain (OS) chickens, but not in normal White Leghorn chickens. Thyroxine antibodies were generally demonstrated at a later time than hemagglutinating thyroglobulin antibodies. By means of absorption experiments, evidence was obtained that thyroxine is present as an antigenic determinant on the chicken thyroglobulin molecule. Thyroxine-binding antibodies occurred in greater frequency in sera with higher hemagglutinating antibody titers. Thyroxine-binding antibodies were present in 22% of chickens with moderate thyroid infiltration and residues of functioning thyroid tissue but only in 9% of chickens with total or almost total destruction of the thyroid tissue. Intravenous injection of OS sera with thyroxine-binding antibodies into normal chicken embryos caused an increase of the mean thyroid follicle diameter. This was explained as due to hypophyseal feedback after binding and inactivation of the thyroxine.

Footnotes

¹ This work was supported by United States Public Health Service Grant CA-02357 from the National Cancer Institute.

² Dr. Nilsson was a Dr. Henry G. and Bertha H. Buswell Research Fellow. Present address: Institute of Medical Microbiology, Department of Bacteriology, University of Göteborg, Guldhedsgatan 10, 413 46 Göteborg, Sweden.

³ Deceased December 7, 1969.

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