The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1971, 107: 1152-1160.
Copyright © 1971 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mizejewski, G. J.
Right arrow Articles by Poissant, G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Mizejewski, G. J.
Right arrow Articles by Poissant, G.

Immunologic Investigations of Naturally Occurring Canine Thyroiditis1

Gerald J. Mizejewski, Jennifer Baron and Gerald Poissant

From the Veterans Administration Hospital and Department of Internal Medicine (Nuclear Medicine), University of Michigan Medical Center, Ann Arbor, Michigan 48105

Abstract

Naturally occurring canine thyroiditis was characterized in the present study by immunodiffusion, passive hemagglutination, complement fixation, immunofluorescence and skin tests. Canine thyroglobulin and thyroid gland extract were used as sources of antigen in all tests. Thyroid histology was examined in all instances. The study mainly concerned 11 beagles, which were classified as thyroiditis colony dogs. Precipitating antibodies were not detectable, while low titers of PHA and varying titers of CF antibodies were present in the sera of the thyroiditis colony dogs. Among the serologic procedures employed, only the fluorescent antibody (FA) tests were consistently positive. The skin test was generally positive in the less progressive stages of the disease. The dog thyroid extract rather than purified thyroglobulin was required for PHA antibody detection. This latter observation, together with the FA staining patterns obtained, implied involvement of the second colloid antigen. Overall evidence from present and past studies suggested that the development of the canine disorder is similar in many respects to human thyroiditis.

Footnotes

1 This work was supported by Grant HD-00688-09 from the United States Public Health Service.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1971 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1971 by The American Association of Immunologists, Inc. All rights reserved.