The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

The Journal of Immunology, 1971, 107: 730-737.
Copyright © 1971 by The American Association of Immunologists, Inc.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fedson, D. S.
Right arrow Articles by Kasel, J. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Fedson, D. S.
Right arrow Articles by Kasel, J. A.

Anti-Neuraminidase Antibody Response in Serum and Nasal Secretions Following Intranasal or Subcutaneous Inactivated A2/Hong Kong/68 Influenza Virus Vaccine1

David S. Fedson, Robert V. Fulk, Margret A. Huber, Margaret A. Reisberg2 and Julius A. Kasel

From the Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

Abstract

The anti-neuraminidase antibody (ANAb) response following subcutaneous or intranasal A2/Hong Kong/68 inactivated influenza virus vaccine was evaluated in 81 volunteers of varying ages. Rises in serum ANAb titer were seen in 33 subjects although 76 developed neutralizing antibody rises. In nasal secretions ANAb rises appeared in only 12 subjects as compared with 31 subjects with neutralizing antibody rises. In individual subjects the magnitude of serum ANAb rises to the Hong Kong neuraminidase and an earlier related A2/1957 neuraminidase were similar. Serum and secretory ANAb cross-reacted considerably with neuraminidase antigens of earlier strains of A2 influenza virus. The enzyme inhibition test for ANAb was more sensitive than the hemagglutination inhibition test. ANAb in nasal secretions was IgA. Since ANAb may participate in host defense against influenza virus infection, it may be important to measure the antibody response to the neuraminidase as well as hemagglutinin antigen to select vaccines with optimal prophylactic activity.

Footnotes

1 This study was supported in part by Grants FR-00350 and HE-05435 from the National Institutes of Health, and the Veterans Administration.

2 Department of Microbiology, Baylor College of Medicine, and the Veterans Administration Hospital, Houston, Texas 77031.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1971 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1971 by The American Association of Immunologists, Inc. All rights reserved.