HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Baker, P. J. Articles by Amsbaugh, D. F. Search for Related Content PubMed Articles by Baker, P. J. Articles by Amsbaugh, D. F.

Characterization of the Antibody Response to Type III Pneumococcal Polysaccharide at the Cellular Level

III. Studies on the Average Avidity of the Antibody Produced by Specific Plaque-Forming Cells

From the Laboratory of Microbial Immunity and the Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014¹

Abstract

A plaque-inhibition test was used to assess the relative avidity of the IgM antibody specific for type III pneumococcal polysaccharide (SSS-III). No changes in avidity were demonstrable at various times after immunization and over a 20,000-fold range of antigen dose. Prior immunization, regardless of the dose of SSS-III employed, resulted in no change in avidity. These results indicated that a restricted population of lymphoid cells participates in the antibody response to SSS-III and that an antigen-mediated cell selection process does not play a significant role.

Footnotes

¹ Laboratory of Microbiology: Dr. Prescott.