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Augmented Anti-S_III Antibody Responses to an S_III-Protein Conjugate¹

From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115

Abstract

Rabbits that had been primed with type III pneumococci (Pn_III) manifested striking anamnestic anti-type-specific polysaccharide (S_III) responses to challenge with a covalent conjugate of S_III and bovine globulin (BGG) if they had received an intervening immunization with BGG. If no supplemental BGG immunization was given, the S_III-BGG complex caused no secondary anti-S_III response in primed animals. Furthermore, a single intravenous dose of S_III-BGG complex elicited a primary anti-S_III antibody response in rabbits. These results were interpreted in the light of cooperative cellular interactions in immune responses. An approach of this sort may be suitable for clinical immunization against a variety of bacterial polysaccharides.

Footnotes

¹ This work was supported in part by Grant AI-09920 from the National Institutes of Health.