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Production and Evaluation of a Formalin-Killed Chikungunya Vaccine¹

From the Walter Reed Army Institute of Research, Washington, D. C. 20012, and the United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21701

Abstract

Production methods and immunogenic characteristics of a formalin-inactivated Chikungunya vaccine prepared in bank-frozen green monkey kidney tissue culture were described. The total absence of untoward reactions or side effects and the excellent immunogenic response in volunteers attested to the safety and immunogenicity of this vaccine.

Footnotes

¹ In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care" as promulgated by the Committee on the Guide for Laboratory Animal Facilities and Care of the Institute of Laboratory Animal Resources, National Academy of Sciences—National Research Council.

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