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Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
Abstract
Immunoelectrophoretic studies of the California encephalitis group (CEV) of arboviruses were carried out. Both single and multiple injection rabbit antisera prepared against the various antigens were used in several agar-buffer-pH systems. Multiple shared antigens were demonstrable among BFS-283 (CE) and all other members of the group except Keystone (KEY) and trivittatus (TVT), thus showing a close antigenic relationship among the majority of members. However, only a minor common antigen was shared between CE and the latter two, indicating a distant antigenic relationship. Guaroa, a member of the Bunyamwera (BUN) group shown by the more conventional neutralization and hemagglutination tests to be related to the CEV group, was found to show a common minor antigen with all members of the CEV group except TVT. At least two common antigens were shared with the latter. Based on this present work and immunodiffusion studies previously reported, it is suggested that the CEV group be considered as a separate group with at least three types. These would be represented by prototypes CE, TVT and KEY. More exhaustive antigenic studies may eventually define additional types and further elucidate the extent of relatedness among members of the CEV and BUN groups.
Footnotes
1 These studies were supported in part by United States Public Health Service Research Grant A1-02686 from the National Institute of Allergy and Infectious Diseases, and in part, under the sponsorship of the Commission on Viral Infections, Armed Forces Epidemiological Board, by the United States Army Medical Research and Development Command, Department of the Army, Contract DA-49-193-MD-2042. In conducting the research described in this report, the investigators adhered to the "Guide for Laboratory Animal Facilities and Care," as promulgated by the Committee on the Guide for Laboratory Animal Resources, National Academy of Sciences-National Research Council.
2 This work is taken in part from a thesis submitted to the Graduate School of Public Health, University of Pittsburgh, as partial requirement for the Doctor of Science in Hygiene degree while a recipient of a fellowship under Training Grant 5 TOI GM-00010 in Epidemiology from the National Institute of General Medical Sciences, National Institutes of Health, United States Public Health Service, supplemented by General Research Support Grant FR 054 51 from the National Institutes of Health. Present address: Epidemiology Research Center, 4001 Tampa Bay Boulevard, Tampa, Florida 33614.
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