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Serum Antigens of Cattle

II. Immunogenetics of Two Immunoglobulin Allotypes¹

Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin 53706, and the Eastern Marketing and Nutritional Research Division, Agriculture Research Service, U.S. Department of Agriculture, Washington, D.C. 20250

Abstract

Two antisera detecting different allotypic specificities, A1 and B1, of cattle immunoglobulins were produced by isoimmunization with purified IgG in Freund's complete adjuvant. The A1 marker was found to be restricted to the Fc portion of IgG2 heavy chains, whereas B1 was a marker of immunoglobulin light chains and was found on IgG, IgA and IgM molecules. Genetic analysis indicated that the alleles controlling A1 and B1, bva¹ and bvb¹, respectively, were autosomal dominants and that they were inherited independently. The bva¹ allele was highly frequent in 11 breeds except Hereford, which showed a low frequency. In contrast, bvb¹ was infrequent or absent in all breeds.

Footnotes

¹ Paper No. 1439 from the Laboratory of Genetics. This study was supported by Grants AI-03204 and GM-15422 from the National Institutes of Health, Grant C00-1210-57 from the Atomic Energy Commission, and Project E6-2-125 of the Eastern Marketing and Nutritional Research Division, United States Department of Agriculture. Published with the permission of the Director, Agricultural Research Station, College of Agriculture and Life Sciences, University of Wisconsin. The senior author acknowledges support from NIH Training Grant GM-00398.

² Present address: Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104.

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