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The Effect of Transplanted Lymphoid Cells, Irradiation, and Drug Therapy on Permanent Immunologic Tolerance¹

Rheumatological Research Department, Copenhagen County Hospital, 2900 Hellerup, Denmark, and the Institute of Medical Microbiology, University of Copenhagen

Abstract

Abolition of the permanent and constant tolerance to lymphocytic choriomeningitis (LCM) virus in inbred mice has hitherto only been possible by transplantation of syngeneic, sensitized or unsensitized lymphoid cells to the tolerant virus-carriers. A series of experiments showed that no essential difference exists between lymphoid cells isolated from the spleens, lymph nodes or buffy coat of hyperimmune, syngeneic mice in their ability to abolish the tolerance of virus-carrier recipients after transplantation. Large numbers of unsensitized thymus cells were without effect. Sensitized bone marrow cells only had a slight effect. Fetal liver cells were without effect. Using the same system with transplantation of lymphoid cells an Eichwald-Silmser effect was found in the highly inbred strain of C3H mice that was used. Large doses of transplanted, killed, syngeneic or living xenogeneic cells had no effect on the tolerance, nor did x-irradiation or treatment with cortisone or methotrexate. Syngeneic, sensitized lymphoid cells in Millipore chambers implanted into tolerant virus-carriers conferred the ability to produce antibody, but the viremia was not essentially affected.

Footnotes

¹ This work was supported by grants from the Einar Willumsen's Memorial Fund and the Danish Cancer Society.