HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Constantine, R. I. Articles by Gordon, J. Search for Related Content PubMed Articles by Constantine, R. I. Articles by Gordon, J.

Graft-vs-Host Reaction in a Xenogeneic Combination: Mechanism of the Reaction

From the Department of Experimental Surgery, McGill University, Montreal, Canada

Abstract

The level of host immunosuppression that allowed development of a localized graft-vs-host (GVH) reaction in a xenogeneic combination was shown to be critical. Immunosuppression had to be sufficient to allow donor cell proliferation, yet permit survival of a low level of host mononuclear cells in the circulation. Furthermore, it had to be of short duration to allow recovery of the immunocompetence of the host in 4 to 6 days. These observations, using cyclophosphamide and anti-lymphocyte serum as immunosuppressive agents and normal and primed donor cells in allogeneic and xenogeneic GVH reactions, suggested that the localized xenogeneic GVH reaction is a composite of an initial GVH followed by a host-vs-graft (HvG) reaction.

Footnotes

¹ Research Associate of the Medical Research Council of Canada.