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Immunochemical Studies on Blood Groups

XLVIII. Activity of Fucose-Containing Oligosaccharides Isolated from Human Urine and from Human Ovarian Cyst A and B Blood Group Substances¹

From the Departments of Microbiology, Neurology, and Human Genetics and Development, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York, New York

Abstract

The immunochemical potency of the blood group A and B specific urinary difucosyl pentasaccharides was compared with that of mono- and difucosyl type 2 reduced oligosaccharides of soluble blood group A and B substances. The urinary difucosyl oligosaccharides were as active as the corresponding difucosyl compounds from blood group substance but were less effective inhibitors than the reduced monofucosyl blood group oligosaccharides in most sera and lectin systems used. With one A anti-A system, however, the urinary A difucosyl pentasaccharide was more active. The difucosyl B oligosaccharides gave slight inhibition in a Le^b anti-Le^b system whereas the difucosyl A pentasaccharide from urine was inactive.

Footnotes

¹ This work was aided by a grant from the National Science Foundation (GB-8341) and a General Research Support Grant from the United States Public Health Service.

² International postdoctoral research fellow (1969–1970) of the United States Public Health Service. Fellowship also supported by the American Scandinavian Foundation.